Neutrophil elastase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q3UP87. Use UniProt Q3UP87 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q3UP87 as the stable identity anchor, then attach disease evidence before program review.
Neutrophil elastase
Review this target as Neutrophil elastase, mapped to UniProt Q3UP87. Sequence length is 265 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neutrophil elastase as ChEMBL target CHEMBL5156, mapped to UniProt Q3UP87. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neutrophil elastase is the right protein anchor across sources, using UniProt Q3UP87 as the stable mapping.
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| Preferred Name | Neutrophil elastase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q3UP87 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neutrophil elastase |
| UniProt Accession | Q3UP87 |
| Component Type | Protein |
| Sequence Length | 265 aa |
Neutrophil elastase
Review this target as Neutrophil elastase, mapped to UniProt Q3UP87. Sequence length is 265 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3617973 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL4112323 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL76688 | 6.84 | IC50 | 145.39 | Clinical |
| CHEMBL515494 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL516292 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL3398148 | 6.72 | IC50 | 190.75 | Preclinical |
| CHEMBL3617968 | 6.16 | Ki | 700.0 | Preclinical |
| CHEMBL1162477 | 5.26 | IC50 | 5490.0 | Preclinical |
| CHEMBL1162478 | 5.1 | IC50 | 7930.0 | Preclinical |
| CHEMBL5594679 | 5.05 | IC50 | 8900.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 5 | 5.7 |
| single protein format | 4 | 6 | 6.8 |