DNA polymerase iota · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q6R3M4. Use UniProt Q6R3M4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6R3M4 as the stable identity anchor, then attach disease evidence before program review.
DNA polymerase iota
Review this target as DNA polymerase iota, mapped to UniProt Q6R3M4. Sequence length is 717 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA polymerase iota as ChEMBL target CHEMBL5159, mapped to UniProt Q6R3M4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | DNA polymerase iota |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q6R3M4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA polymerase iota |
| UniProt Accession | Q6R3M4 |
| Component Type | Protein |
| Sequence Length | 717 aa |
DNA polymerase iota
Review this target as DNA polymerase iota, mapped to UniProt Q6R3M4. Sequence length is 717 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1917196 | 5.15 | IC50 | 7100.0 | Preclinical |
| CHEMBL1917198 | 5.06 | IC50 | 8700.0 | Preclinical |
| CHEMBL457041 | 4.7 | IC50 | 19800.0 | Preclinical |
| CHEMBL513800 | 4.49 | IC50 | 32500.0 | Preclinical |
| CHEMBL3593571 | 4.47 | IC50 | 34000.0 | Preclinical |
| CHEMBL2011646 | 4.3 | IC50 | 50200.0 | Preclinical |
| CHEMBL2011648 | 4.2 | IC50 | 63800.0 | Preclinical |
| CHEMBL2011647 | 4.04 | IC50 | 91000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 8 | 4.5 |