NPC1-like intracellular cholesterol transporter 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q6T3U3. Use UniProt Q6T3U3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6T3U3 as the stable identity anchor, then attach disease evidence before program review.
NPC1-like intracellular cholesterol transporter 1
Review this target as NPC1-like intracellular cholesterol transporter 1, mapped to UniProt Q6T3U3. Sequence length is 1331 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NPC1-like intracellular cholesterol transporter 1 as ChEMBL target CHEMBL5161, mapped to UniProt Q6T3U3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NPC1-like intracellular cholesterol transporter 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q6T3U3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NPC1-like intracellular cholesterol transporter 1 |
| UniProt Accession | Q6T3U3 |
| Component Type | Protein |
| Sequence Length | 1331 aa |
NPC1-like intracellular cholesterol transporter 1
Review this target as NPC1-like intracellular cholesterol transporter 1, mapped to UniProt Q6T3U3. Sequence length is 1331 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL578400 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL504066 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL578401 | 6.9 | IC50 | 127.0 | Preclinical |
| CHEMBL321017 | 6.75 | Ki | 180.0 | Preclinical |
| CHEMBL1138 | 6.7 | Ki | 200.0 | Approved |
| CHEMBL321017 | 6.24 | IC50 | 580.0 | Preclinical |
| CHEMBL271655 | 5.85 | Ki | 1400.0 | Preclinical |
| CHEMBL271634 | 5.64 | Ki | 2300.0 | Preclinical |
| CHEMBL258358 | 5.44 | Ki | 3600.0 | Preclinical |
| CHEMBL257848 | 5.32 | Ki | 4800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 29 | 5.4 |
| cell-based format | 1 | 2 | 7.6 |