Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt A0A0G2K344. Use UniProt A0A0G2K344 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt A0A0G2K344 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt A0A0G2K344. Sequence length is 1068 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform as ChEMBL target CHEMBL5169092, mapped to UniProt A0A0G2K344. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | A0A0G2K344 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| UniProt Accession | A0A0G2K344 |
| Component Type | Protein |
| Sequence Length | 1068 aa |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt A0A0G2K344. Sequence length is 1068 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1879463 | 8.28 | IC50 | 5.3 | Clinical |
| CHEMBL5805802 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL5921250 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL5859013 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL5174001 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL5203121 | 7.38 | IC50 | 42.0 | Preclinical |
| CHEMBL5832370 | 7.34 | IC50 | 46.0 | Preclinical |
| CHEMBL5177354 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL521851 | 7.28 | IC50 | 52.0 | Clinical |
| CHEMBL2017976 | 7.2 | IC50 | 63.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 54 | 6.7 |