Use UniProt Q3UHJ0 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL5169154 Target Snapshot
AP2-associated protein kinase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q3UHJ0. Use UniProt Q3UHJ0 as the stable identity anchor, then attach disease evidence before program review.
AP2-associated protein kinase 1
Review this target as AP2-associated protein kinase 1, mapped to UniProt Q3UHJ0. Sequence length is 959 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats AP2-associated protein kinase 1 as ChEMBL target CHEMBL5169154, mapped to UniProt Q3UHJ0. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | AP2-associated protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q3UHJ0 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | AP2-associated protein kinase 1 |
| UniProt Accession | Q3UHJ0 |
| Component Type | Protein |
| Sequence Length | 959 aa |
AP2-associated protein kinase 1
How to read this target
Review this target as AP2-associated protein kinase 1, mapped to UniProt Q3UHJ0. Sequence length is 959 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4534648 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL5179172 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL5183016 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL5185616 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL5202370 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL5202896 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL4084103 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5178261 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5199698 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5204340 | 10.3 | Ki | 0.05 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Functional — 11 assays, 1 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 11 | 1 | 5.1 |
Binding — 1 assays, 47 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 47 | 9.6 |