DNA oxidative demethylase ALKBH2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6NS38. Use UniProt Q6NS38 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6NS38 as the stable identity anchor, then attach disease evidence before program review.
DNA oxidative demethylase ALKBH2
Review this target as DNA oxidative demethylase ALKBH2, mapped to UniProt Q6NS38. Sequence length is 261 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA oxidative demethylase ALKBH2 as ChEMBL target CHEMBL5169164, mapped to UniProt Q6NS38. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | DNA oxidative demethylase ALKBH2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6NS38 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA oxidative demethylase ALKBH2 |
| UniProt Accession | Q6NS38 |
| Component Type | Protein |
| Sequence Length | 261 aa |
DNA oxidative demethylase ALKBH2
Review this target as DNA oxidative demethylase ALKBH2, mapped to UniProt Q6NS38. Sequence length is 261 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL418068 | 5.04 | IC50 | 9100.0 | Preclinical |
| CHEMBL5285500 | 4.97 | IC50 | 10800.0 | Preclinical |
| CHEMBL5169684 | 4.86 | IC50 | 13800.0 | Preclinical |
| CHEMBL5173876 | 4.59 | IC50 | 25900.0 | Preclinical |
| CHEMBL5269140 | 4.59 | IC50 | 25800.0 | Preclinical |
| CHEMBL5288180 | 4.37 | IC50 | 42700.0 | Preclinical |
| CHEMBL5288308 | 4.33 | IC50 | 46200.0 | Preclinical |
| CHEMBL5266761 | 4.25 | IC50 | 56600.0 | Preclinical |
| CHEMBL5282569 | 4.25 | IC50 | 56400.0 | Preclinical |
| CHEMBL5286685 | 4.19 | IC50 | 65200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 2 | 5.0 |
| cell-based format | 3 | 13 | 4.5 |
| assay format | 1 | 2 | — |