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Target Snapshot

CHEMBL5169229 Target Snapshot

Type II NADH:quinone oxidoreductase NdhA · SINGLE PROTEIN · Mycobacterium tuberculosis

7Compounds
1Assays
0Approved Drugs
7.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P95200. Use UniProt P95200 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P95200 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Type II NADH:quinone oxidoreductase NdhA as ChEMBL target CHEMBL5169229, mapped to UniProt P95200. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Type II NADH:quinone oxidoreductase NdhA
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-14
ChEMBL target ID
CHEMBL5169229
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P95200
Type II NADH:quinone oxidoreductase NdhA
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Type II NADH:quinone oxidoreductase NdhA is the right protein anchor across sources, using UniProt P95200 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelType II NADH:quinone oxidoreductase NdhA
UniProt AccessionP95200
Component TypeProtein
Sequence Length470 aa

Type II NADH:quinone oxidoreductase NdhA

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Type II NADH:quinone oxidoreductase NdhA, mapped to UniProt P95200. Sequence length is 470 aa.

Mapped IDP95200
Review nameType II NADH:quinone oxidoreductase NdhA
OrganismMycobacterium tuberculosis
Assay Mix

Activity Type Distribution

IC507.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5186518 7.24 IC50 57.0 Preclinical
CHEMBL5201484 7.23 IC50 59.0 Preclinical
CHEMBL5171834 7.02 IC50 96.0 Preclinical
CHEMBL5202255 6.48 IC50 330.0 Preclinical
CHEMBL5182198 6.01 IC50 980.0 Preclinical
CHEMBL5206556 5.63 IC50 2340.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
2
6.0
0
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 6 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine