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Target Snapshot

CHEMBL5169266 Target Snapshot

BCL2/BAD · PROTEIN-PROTEIN INTERACTION · Homo sapiens

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129Compounds
5Assays
0Approved Drugs
286.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q92934. Use UniProt Q92934 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q92934 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BCL2/BAD as ChEMBL target CHEMBL5169266, mapped to UniProt Q92934. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BCL2/BAD
PROTEIN-PROTEIN INTERACTION · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5169266
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q92934
Bcl2-associated agonist of cell death
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BCL2/BAD is the right protein anchor across sources, using UniProt Q92934 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBCL2/BAD
Target TypePROTEIN-PROTEIN INTERACTION
OrganismHomo sapiens
UniProtQ92934
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBcl2-associated agonist of cell death
UniProt AccessionQ92934
Component TypeProtein
Sequence Length168 aa

Bcl2-associated agonist of cell death

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BCL2/BAD, mapped to UniProt Q92934. ChEMBL maps the protein component as Bcl2-associated agonist of cell death. Sequence length is 168 aa.

Mapped IDQ92934
Review nameBCL2/BAD
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC50285.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL297453 6.31 Ki 490.0 Clinical
CHEMBL5886592 4.92 IC50 12000.0 Preclinical
CHEMBL5904417 4.92 IC50 12000.0 Preclinical
CHEMBL5941324 4.92 IC50 12000.0 Preclinical
CHEMBL5861078 4.91 IC50 12200.0 Preclinical
CHEMBL6061347 4.88 IC50 13200.0 Preclinical
CHEMBL5742152 4.85 IC50 14000.0 Preclinical
CHEMBL5763676 4.85 IC50 14000.0 Preclinical
CHEMBL5771735 4.85 IC50 14000.0 Preclinical
CHEMBL5800744 4.85 IC50 14100.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
35
Tested Compounds
1
Assay Types
Binding — 5 assays, 35 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 25 4.8
protein format 2 10 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine