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Target Snapshot

CHEMBL5169268 Target Snapshot

BCL2A1/BID · PROTEIN-PROTEIN INTERACTION · Homo sapiens

64Compounds
7Assays
0Approved Drugs
64.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q16548. Use UniProt Q16548 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q16548 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BCL2A1/BID as ChEMBL target CHEMBL5169268, mapped to UniProt Q16548. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BCL2A1/BID
PROTEIN-PROTEIN INTERACTION · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5169268
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q16548
Bcl-2-related protein A1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BCL2A1/BID is the right protein anchor across sources, using UniProt Q16548 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBcl-2-related protein A1
UniProt AccessionQ16548
Component TypeProtein
Sequence Length175 aa

Bcl-2-related protein A1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as BCL2A1/BID, mapped to UniProt Q16548. ChEMBL maps the protein component as Bcl-2-related protein A1. Sequence length is 175 aa.

Mapped IDQ16548
Review nameBCL2A1/BID
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC505.0
KI58.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5523629 6.98 Ki 105.0 Preclinical
CHEMBL5549784 6.96 Ki 110.0 Preclinical
CHEMBL5558580 6.91 Ki 124.0 Preclinical
CHEMBL5558391 6.9 Ki 127.0 Preclinical
CHEMBL5532559 6.85 Ki 140.0 Preclinical
CHEMBL5518045 6.84 Ki 145.0 Preclinical
CHEMBL5559447 6.8 Ki 158.0 Preclinical
CHEMBL5558174 6.75 Ki 178.0 Preclinical
CHEMBL5557494 6.66 Ki 218.0 Preclinical
CHEMBL5542437 6.6 Ki 251.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
5
5.5
17
6.0
11
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
37
Tested Compounds
1
Assay Types
Binding — 7 assays, 37 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 7 37 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine