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Target Snapshot

CHEMBL5209888 Target Snapshot

SW620/5-FU · CELL-LINE · Homo sapiens

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45Compounds
62Assays
0Approved Drugs
55.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW620/5-FU as ChEMBL target CHEMBL5209888. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW620/5-FU
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5209888
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW620/5-FU still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW620/5-FU
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW620/5-FU
UniProt AccessionN/A

SW620/5-FU

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW620/5-FU.

Review nameSW620/5-FU
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5020.0
EC5035.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5208524 5.7 IC50 1990.0 Preclinical
CHEMBL5181599 5.67 IC50 2150.0 Preclinical
CHEMBL3401388 5.53 IC50 2940.0 Preclinical
CHEMBL5193759 5.49 IC50 3210.0 Preclinical
CHEMBL5206290 5.45 IC50 3560.0 Preclinical
CHEMBL5172220 5.44 IC50 3650.0 Preclinical
CHEMBL5206026 5.23 IC50 5840.0 Preclinical
CHEMBL5175095 5.04 EC50 9150.0 Preclinical
CHEMBL5171726 5.01 EC50 9700.0 Preclinical
CHEMBL5195317 4.93 EC50 11650.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

62
Total Assays
40
Tested Compounds
1
Assay Types
Functional — 62 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 40 4.7
organism-based format 31 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine