Polyunsaturated fatty acid 5-lipoxygenase · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P48999. Use UniProt P48999 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48999 as the stable identity anchor, then attach disease evidence before program review.
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as Polyunsaturated fatty acid 5-lipoxygenase, mapped to UniProt P48999. Sequence length is 674 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polyunsaturated fatty acid 5-lipoxygenase as ChEMBL target CHEMBL5211, mapped to UniProt P48999. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Polyunsaturated fatty acid 5-lipoxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P48999 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polyunsaturated fatty acid 5-lipoxygenase |
| UniProt Accession | P48999 |
| Component Type | Protein |
| Sequence Length | 674 aa |
Polyunsaturated fatty acid 5-lipoxygenase
Review this target as Polyunsaturated fatty acid 5-lipoxygenase, mapped to UniProt P48999. Sequence length is 674 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL22106 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL21880 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL442334 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL20599 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL70191 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL70054 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL423835 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL283559 | 8.02 | IC50 | 9.6 | Preclinical |
| CHEMBL440461 | 7.91 | IC50 | 12.3 | Preclinical |
| CHEMBL20953 | 7.85 | IC50 | 14.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 57 | 6.2 |
| cell-based format | 1 | 4 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 2 | 0 | — |
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |