IMI-1 · SINGLE PROTEIN · Enterobacter cloacae
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q46991. Use UniProt Q46991 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q46991 as the stable identity anchor, then attach disease evidence before program review.
beta-lactamase
Review this target as IMI-1, mapped to UniProt Q46991. ChEMBL maps the protein component as beta-lactamase. Sequence length is 292 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats IMI-1 as ChEMBL target CHEMBL5219, mapped to UniProt Q46991. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether IMI-1 is the right protein anchor across sources, using UniProt Q46991 as the stable mapping.
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| Preferred Name | IMI-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Enterobacter cloacae |
| UniProt | Q46991 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | beta-lactamase |
| UniProt Accession | Q46991 |
| Component Type | Protein |
| Sequence Length | 292 aa |
beta-lactamase
Review this target as IMI-1, mapped to UniProt Q46991. ChEMBL maps the protein component as beta-lactamase. Sequence length is 292 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL263746 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL331090 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL404 | 7.52 | IC50 | 30.0 | Approved |
| CHEMBL124416 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL122450 | 7.14 | IC50 | 72.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 7.5 |
| single protein format | 2 | 5 | 7.5 |