Dihydrofolate reductase-thymidylate synthase · SINGLE PROTEIN · Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
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As of 2026-09-14Protein identity stays anchored to UniProt Q582G3. Use UniProt Q582G3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q582G3 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q582G3. ChEMBL maps the protein component as Bifunctional dihydrofolate reductase-thymidylate synthase. Sequence length is 527 aa.
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This review treats Dihydrofolate reductase-thymidylate synthase as ChEMBL target CHEMBL5229, mapped to UniProt Q582G3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase-thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
| UniProt | Q582G3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional dihydrofolate reductase-thymidylate synthase |
| UniProt Accession | Q582G3 |
| Component Type | Protein |
| Sequence Length | 527 aa |
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q582G3. ChEMBL maps the protein component as Bifunctional dihydrofolate reductase-thymidylate synthase. Sequence length is 527 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL426 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5199171 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL1232702 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL5201183 | 6.47 | IC50 | 340.0 | Preclinical |
| CHEMBL5171609 | 6.37 | IC50 | 430.0 | Preclinical |
| CHEMBL26006 | 6.35 | IC50 | 450.0 | Preclinical |
| CHEMBL5200612 | 6.23 | IC50 | 590.0 | Preclinical |
| CHEMBL5180552 | 6.21 | IC50 | 620.0 | Preclinical |
| CHEMBL5183748 | 6.21 | IC50 | 620.0 | Preclinical |
| CHEMBL5182291 | 6.01 | IC50 | 980.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |
| cell-based format | 1 | 34 | 5.5 |