Tyrosine-protein kinase JAK3 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q62137. Use UniProt Q62137 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q62137 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase JAK3
Review this target as Tyrosine-protein kinase JAK3, mapped to UniProt Q62137. Sequence length is 1100 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase JAK3 as ChEMBL target CHEMBL5250, mapped to UniProt Q62137. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase JAK3 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q62137 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK3 |
| UniProt Accession | Q62137 |
| Component Type | Protein |
| Sequence Length | 1100 aa |
Tyrosine-protein kinase JAK3
Review this target as Tyrosine-protein kinase JAK3, mapped to UniProt Q62137. Sequence length is 1100 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL221959 | 7.32 | IC50 | 48.0 | Approved |
| CHEMBL3039513 | 7.3 | IC50 | 50.0 | Clinical |
| CHEMBL4776512 | 6.25 | IC50 | 563.7 | Preclinical |
| CHEMBL4564280 | 6.12 | IC50 | 764.0 | Preclinical |
| CHEMBL4746272 | 6.11 | IC50 | 770.0 | Preclinical |
| CHEMBL3940537 | 6.07 | IC50 | 848.0 | Preclinical |
| CHEMBL1650951 | 5.89 | IC50 | 1294.0 | Preclinical |
| CHEMBL4750184 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL3966342 | 5.76 | IC50 | 1724.0 | Preclinical |
| CHEMBL3622821 | 5.73 | IC50 | 1860.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 14 | 5.9 |
| tissue-based format | 4 | 0 | — |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 3 | 6.3 |