Tyrosine-protein kinase BTK · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tyrosine-protein kinase BTK shows approved-linked disease relevance led by chronic lymphocytic leukemia. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q06187. Start with chronic lymphocytic leukemia, then reuse UniProt Q06187 as the stable protein anchor across project notes and exports.
Start with chronic lymphocytic leukemia, then reuse UniProt Q06187 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase BTK shows approved-linked disease relevance led by chronic lymphocytic leukemia. 5 more disease programs remain visible in the same review block. 8 linked drugs remain visible in the same block.
Start review with chronic lymphocytic leukemia because it currently carries approved-linked support. Linked drugs include ACALABRUTINIB, ACALABRUTINIB MALEATE, EDRALBRUTINIB, IBRUTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase BTK
Review this target as Tyrosine-protein kinase BTK, mapped to UniProt Q06187. Sequence length is 659 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase BTK as ChEMBL target CHEMBL5251, mapped to UniProt Q06187. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tyrosine-protein kinase BTK is the right protein anchor across sources, using UniProt Q06187 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why chronic lymphocytic leukemia is currently framed as approved-linked support. It currently carries 8 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosine-protein kinase BTK |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q06187 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase BTK |
| UniProt Accession | Q06187 |
| Component Type | Protein |
| Sequence Length | 659 aa |
Tyrosine-protein kinase BTK
Review this target as Tyrosine-protein kinase BTK, mapped to UniProt Q06187. Sequence length is 659 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase BTK shows approved-linked disease relevance led by chronic lymphocytic leukemia. 5 more disease programs remain visible in the same review block.
Start review with chronic lymphocytic leukemia because it currently carries approved-linked support. Linked drugs include ACALABRUTINIB, ACALABRUTINIB MALEATE, EDRALBRUTINIB, IBRUTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4762397 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL5977366 | 10.54 | IC50 | 0.029 | Preclinical |
| CHEMBL5945342 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL5826570 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL5884405 | 10.35 | IC50 | 0.045 | Preclinical |
| CHEMBL5909954 | 10.34 | IC50 | 0.046 | Preclinical |
| CHEMBL5789446 | 10.33 | IC50 | 0.047 | Preclinical |
| CHEMBL5749648 | 10.31 | IC50 | 0.049 | Preclinical |
| CHEMBL5799170 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL5741138 | 10.3 | IC50 | 0.05 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 959 | 6,794 | 7.7 |
| cell-based format | 407 | 1,784 | 7.7 |
| assay format | 183 | 2,307 | 7.3 |
| tissue-based format | 33 | 192 | 7.2 |
| subcellular format | 16 | 31 | 6.3 |
| cell membrane format | 1 | 1 | 7.8 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 3 | 6.8 |
| assay format | 3 | 143 | 6.2 |
| organism-based format | 3 | 0 | — |
| tissue-based format | 3 | 1 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
| single protein format | 1 | 0 | — |