Cytochrome P450 2E1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P05181. Use UniProt P05181 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05181 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2E1
Review this target as Cytochrome P450 2E1, mapped to UniProt P05181. Sequence length is 493 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2E1 as ChEMBL target CHEMBL5281, mapped to UniProt P05181. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cytochrome P450 2E1 is the right protein anchor across sources, using UniProt P05181 as the stable mapping.
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| Preferred Name | Cytochrome P450 2E1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P05181 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2E1 |
| UniProt Accession | P05181 |
| Component Type | Protein |
| Sequence Length | 493 aa |
Cytochrome P450 2E1
Review this target as Cytochrome P450 2E1, mapped to UniProt P05181. Sequence length is 493 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL215134 | 7.4 | Ki | 40.0 | Preclinical |
| CHEMBL214784 | 7.3 | Ki | 50.0 | Preclinical |
| CHEMBL214784 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL386124 | 6.7 | Ki | 200.0 | Preclinical |
| CHEMBL4161819 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL386124 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL178780 | 6.24 | IC50 | 580.0 | Preclinical |
| CHEMBL215174 | 6.22 | Ki | 600.0 | Preclinical |
| CHEMBL214859 | 6.1 | Ki | 800.0 | Preclinical |
| CHEMBL214990 | 6.1 | Ki | 800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 90 | 39 | 5.3 |
| assay format | 53 | 3 | 4.3 |
| microsome format | 43 | 62 | 4.7 |
| cell-based format | 8 | 0 | — |
| tissue-based format | 7 | 0 | — |
| organism-based format | 1 | 1 | 4.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 4 | 5.5 |
| cell-based format | 1 | 1 | 5.0 |