Sphingolipid delta(4)-desaturase DES1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q5XIF5. Use UniProt Q5XIF5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5XIF5 as the stable identity anchor, then attach disease evidence before program review.
Sphingolipid delta(4)-desaturase DES1
Review this target as Sphingolipid delta(4)-desaturase DES1, mapped to UniProt Q5XIF5. Sequence length is 323 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sphingolipid delta(4)-desaturase DES1 as ChEMBL target CHEMBL5291552, mapped to UniProt Q5XIF5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sphingolipid delta(4)-desaturase DES1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q5XIF5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sphingolipid delta(4)-desaturase DES1 |
| UniProt Accession | Q5XIF5 |
| Component Type | Protein |
| Sequence Length | 323 aa |
Sphingolipid delta(4)-desaturase DES1
Review this target as Sphingolipid delta(4)-desaturase DES1, mapped to UniProt Q5XIF5. Sequence length is 323 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5275998 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5290345 | 5.78 | IC50 | 1680.0 | Preclinical |
| CHEMBL7301 | 5.63 | IC50 | 2320.0 | Clinical |
| CHEMBL5277675 | 5.09 | IC50 | 8200.0 | Preclinical |
| CHEMBL7301 | 5.08 | Ki | 8280.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 4 | 4 | 6.0 |