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Target Snapshot

CHEMBL5303 Target Snapshot

PER-2 beta-lactamase · SINGLE PROTEIN · Citrobacter freundii

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15Compounds
4Assays
5Approved Drugs
6.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt A2RP81. Use UniProt A2RP81 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A2RP81 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PER-2 beta-lactamase as ChEMBL target CHEMBL5303, mapped to UniProt A2RP81. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PER-2 beta-lactamase
SINGLE PROTEIN · Citrobacter freundii
As of 2026-09-13
ChEMBL target ID
CHEMBL5303
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
A2RP81
Beta-lactamase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PER-2 beta-lactamase is the right protein anchor across sources, using UniProt A2RP81 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePER-2 beta-lactamase
Target TypeSINGLE PROTEIN
OrganismCitrobacter freundii
UniProtA2RP81
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase
UniProt AccessionA2RP81
Component TypeProtein
Sequence Length308 aa

Beta-lactamase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PER-2 beta-lactamase, mapped to UniProt A2RP81. ChEMBL maps the protein component as Beta-lactamase. Sequence length is 308 aa.

Mapped IDA2RP81
Review namePER-2 beta-lactamase
OrganismCitrobacter freundii
Clinical Profile

Clinical Phase Distribution

5
Approved
Assay Mix

Activity Type Distribution

IC502.0
KI4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL148 7.22 Ki 60.0 Approved
CHEMBL9306 7.17 IC50 68.0 Preclinical
CHEMBL404 7.02 IC50 96.0 Approved
CHEMBL996 6.85 Ki 140.0 Approved
CHEMBL702 6.7 Ki 200.0 Approved
CHEMBL158 5.7 Ki 2000.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
2
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
IMIPENEM ANHYDROUS
CHEMBL148
Approved 1985
Properties Compare Identifier
PIPERACILLIN
CHEMBL702
Approved 1981
Properties Compare Identifier
CEFOXITIN
CHEMBL996
Approved 1978
Properties Compare Identifier
Assay Landscape

Assay Landscape

4
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 4 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 6 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine