ROS1-SDC4 · CHIMERIC PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13ROS1-SDC4 shows approved-linked disease relevance led by cancer. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P08922. Start with cancer, then reuse UniProt P08922 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P08922 as the stable protein anchor across project notes and exports.
ROS1-SDC4 shows approved-linked disease relevance led by cancer. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include REPOTRECTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProto-oncogene tyrosine-protein kinase ROS
Review this target as ROS1-SDC4, mapped to UniProt P08922. ChEMBL maps the protein component as Proto-oncogene tyrosine-protein kinase ROS. Sequence length is 2347 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ROS1-SDC4 as ChEMBL target CHEMBL5303568, mapped to UniProt P08922. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether ROS1-SDC4 is the right protein anchor across sources, using UniProt P08922 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | ROS1-SDC4 |
| Target Type | CHIMERIC PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08922 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Proto-oncogene tyrosine-protein kinase ROS |
| UniProt Accession | P08922 |
| Component Type | Protein |
| Sequence Length | 2347 aa |
Proto-oncogene tyrosine-protein kinase ROS
Review this target as ROS1-SDC4, mapped to UniProt P08922. ChEMBL maps the protein component as Proto-oncogene tyrosine-protein kinase ROS. Sequence length is 2347 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
ROS1-SDC4 shows approved-linked disease relevance led by cancer. 3 more disease programs remain visible in the same review block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include REPOTRECTINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3545311 | 7.8 | IC50 | 16.0 | Approved |
| CHEMBL601719 | 7.77 | IC50 | 17.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 7.8 |