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Target Snapshot

CHEMBL5306 Target Snapshot

Motilin receptor · SINGLE PROTEIN · Oryctolagus cuniculus

122Compounds
17Assays
1Approved Drugs
160.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt A5A4K8. Use UniProt A5A4K8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A5A4K8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Motilin receptor as ChEMBL target CHEMBL5306, mapped to UniProt A5A4K8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Motilin receptor
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5306
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
A5A4K8
Motilin receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Motilin receptor is the right protein anchor across sources, using UniProt A5A4K8 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMotilin receptor
UniProt AccessionA5A4K8
Component TypeProtein
Sequence Length400 aa

Motilin receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Motilin receptor, mapped to UniProt A5A4K8. Sequence length is 400 aa.

Mapped IDA5A4K8
Review nameMotilin receptor
OrganismOryctolagus cuniculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5078.0
EC5072.0
KD10.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL496391 8.96 IC50 1.1 Preclinical
CHEMBL289955 8.75 IC50 1.778 Preclinical
CHEMBL45141 8.73 IC50 1.862 Preclinical
CHEMBL496191 8.72 IC50 1.9 Preclinical
CHEMBL297168 8.64 IC50 2.291 Preclinical
CHEMBL496190 8.6 Kd 2.512 Preclinical
CHEMBL26966 8.5 IC50 3.162 Preclinical
CHEMBL300004 8.47 IC50 3.388 Preclinical
CHEMBL43313 8.46 IC50 3.467 Preclinical
CHEMBL265495 8.42 IC50 3.802 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
12
5.5
18
6.0
26
6.5
35
7.0
19
7.5
27
8.0
9
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
74
Tested Compounds
2
Assay Types
Functional — 9 assays, 74 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 7 65 6.8
organism-based format 1 0
tissue-based format 1 9 7.6
Binding — 8 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 35 7.0
tissue-based format 2 8 8.3
assay format 1 10 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine