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Target Snapshot

CHEMBL5310 Target Snapshot

Activin receptor type-1B · SINGLE PROTEIN · Homo sapiens

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955Compounds
280Assays
5Approved Drugs
693.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P36896. Use UniProt P36896 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P36896 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Activin receptor type-1B as ChEMBL target CHEMBL5310, mapped to UniProt P36896. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Activin receptor type-1B
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5310
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P36896
Activin receptor type-1B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Activin receptor type-1B is the right protein anchor across sources, using UniProt P36896 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameActivin receptor type-1B
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP36896
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelActivin receptor type-1B
UniProt AccessionP36896
Component TypeProtein
Sequence Length505 aa

Activin receptor type-1B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Activin receptor type-1B, mapped to UniProt P36896. Sequence length is 505 aa.

Mapped IDP36896
Review nameActivin receptor type-1B
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
3
Phase III
10
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50320.0
EC507.0
KD366.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL400402 9.0 Kd 1.0 Preclinical
CHEMBL5591770 8.68 IC50 2.1 Preclinical
CHEMBL5897331 8.57 IC50 2.7 Preclinical
CHEMBL5813038 8.43 IC50 3.7 Preclinical
CHEMBL5903130 8.43 IC50 3.7 Preclinical
CHEMBL253969 8.4 Kd 4.0 Clinical
CHEMBL5595138 8.33 IC50 4.7 Preclinical
CHEMBL5818729 8.32 IC50 4.8 Preclinical
CHEMBL5288333 8.07 IC50 8.6 Preclinical
CHEMBL1908395 8.0 Kd 10.0 Preclinical
Distribution

pChEMBL Value Distribution

40
5.0
33
5.5
40
6.0
39
6.5
38
7.0
39
7.5
16
8.0
4
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DABRAFENIB
CHEMBL2028663
Approved 2013
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

280
Total Assays
166
Tested Compounds
3
Assay Types
Binding — 276 assays, 166 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 206 134 6.3
assay format 37 5 6.4
cell-based format 24 11 6.3
subcellular format 9 16 6.5
ADME — 3 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 10 6.2
Functional — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine