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Target Snapshot

CHEMBL5314311 Target Snapshot

Astrocyte · CELL-LINE · Mus musculus

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43Compounds
18Assays
0Approved Drugs
15.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Astrocyte as ChEMBL target CHEMBL5314311. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Astrocyte
CELL-LINE · Mus musculus
As of 2026-09-15
ChEMBL target ID
CHEMBL5314311
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Astrocyte still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAstrocyte
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAstrocyte
UniProt AccessionN/A

Astrocyte

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Astrocyte.

Review nameAstrocyte
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4284717 6.4 IC50 400.0 Preclinical
CHEMBL4280206 6.22 IC50 600.0 Preclinical
CHEMBL4276776 6.0 IC50 1000.0 Preclinical
CHEMBL4285772 5.7 IC50 2000.0 Preclinical
CHEMBL4293646 5.24 IC50 5800.0 Preclinical
CHEMBL4291079 4.7 IC50 20000.0 Preclinical
CHEMBL4280452 4.66 IC50 22000.0 Preclinical
CHEMBL4287656 4.64 IC50 23000.0 Preclinical
CHEMBL1257065 4.33 IC50 47000.0 Clinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
3
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

18
Total Assays
12
Tested Compounds
3
Assay Types
ADME — 10 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 12 5.3
Toxicity — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 0 —
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine