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Target Snapshot

CHEMBL5314314 Target Snapshot

Cortical neurone · CELL-LINE · Mus musculus

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190Compounds
72Assays
1Approved Drugs
20.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cortical neurone as ChEMBL target CHEMBL5314314. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cortical neurone
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5314314
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cortical neurone still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCortical neurone
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCortical neurone
UniProt AccessionN/A

Cortical neurone

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cortical neurone.

Review nameCortical neurone
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5017.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1908360 9.82 IC50 0.15 Approved
CHEMBL4518369 7.52 IC50 30.0 Preclinical
CHEMBL3219283 6.52 EC50 300.0 Preclinical
CHEMBL4539102 6.48 IC50 334.0 Preclinical
CHEMBL4463715 6.34 IC50 452.0 Preclinical
CHEMBL4439129 5.94 IC50 1150.0 Preclinical
CHEMBL4514017 5.88 IC50 1310.0 Preclinical
CHEMBL4463919 5.74 IC50 1830.0 Preclinical
CHEMBL4451779 5.63 IC50 2350.0 Preclinical
CHEMBL45245 5.62 EC50 2373.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
8
5.5
2
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

EVEROLIMUS
CHEMBL1908360
Approved 2009
Properties Compare Identifier
Assay Landscape

Assay Landscape

72
Total Assays
20
Tested Compounds
3
Assay Types
Functional — 54 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 48 20 6.0
assay format 6 0 —
Toxicity — 13 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 0 —
ADME — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine