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Target Snapshot

CHEMBL5314330 Target Snapshot

Peritoneal macrophage · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
1,128Compounds
253Assays
4Approved Drugs
204.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peritoneal macrophage as ChEMBL target CHEMBL5314330. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peritoneal macrophage
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL5314330
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Peritoneal macrophage still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePeritoneal macrophage
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPeritoneal macrophage
UniProt AccessionN/A

Peritoneal macrophage

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Peritoneal macrophage.

Review namePeritoneal macrophage
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
2
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50159.0
EC5045.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4784510 8.7 EC50 2.0 Preclinical
CHEMBL4281588 7.95 IC50 11.2 Preclinical
CHEMBL4537850 7.85 IC50 14.1 Preclinical
CHEMBL4573465 7.84 IC50 14.6 Preclinical
CHEMBL4292211 7.31 IC50 48.9 Preclinical
CHEMBL5431161 7.19 IC50 65.0 Preclinical
CHEMBL4471265 7.15 IC50 70.7 Preclinical
CHEMBL4451891 7.06 IC50 87.6 Preclinical
CHEMBL5398877 6.94 IC50 114.0 Preclinical
CHEMBL5430841 6.88 IC50 131.0 Preclinical
Distribution

pChEMBL Value Distribution

30
5.0
18
5.5
6
6.0
6
6.5
5
7.0
4
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DEXAMETHASONE
CHEMBL384467
Approved 1958
Properties Compare Identifier
Assay Landscape

Assay Landscape

253
Total Assays
63
Tested Compounds
3
Assay Types
Functional — 175 assays, 63 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 170 52 5.8
assay format 5 11 4.5
ADME — 51 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 51 61 4.6
Toxicity — 27 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 4 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine