Cyclin-dependent kinase 18 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q07002. Use UniProt Q07002 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q07002 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 18
Review this target as Cyclin-dependent kinase 18, mapped to UniProt Q07002. Sequence length is 474 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase 18 as ChEMBL target CHEMBL5316, mapped to UniProt Q07002. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-dependent kinase 18 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q07002 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 18 |
| UniProt Accession | Q07002 |
| Component Type | Protein |
| Sequence Length | 474 aa |
Cyclin-dependent kinase 18
Review this target as Cyclin-dependent kinase 18, mapped to UniProt Q07002. Sequence length is 474 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL445813 | 7.85 | Kd | 14.0 | Clinical |
| CHEMBL384304 | 7.7 | Kd | 20.0 | Clinical |
| CHEMBL296468 | 7.36 | Kd | 44.0 | Preclinical |
| CHEMBL574738 | 7.27 | Kd | 54.0 | Preclinical |
| CHEMBL3128043 | 7.17 | Kd | 67.0 | Preclinical |
| CHEMBL1082152 | 6.96 | Kd | 110.0 | Preclinical |
| CHEMBL1230609 | 6.6 | Kd | 250.0 | Clinical |
| CHEMBL388978 | 6.57 | Kd | 270.0 | Preclinical |
| CHEMBL502835 | 6.29 | Kd | 510.0 | Approved |
| CHEMBL4088216 | 6.0 | IC50 | 1000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 77 | 22 | 6.2 |
| assay format | 17 | 0 | — |
| cell-based format | 13 | 0 | — |
| subcellular format | 12 | 1 | 7.2 |