Apoptosis regulator BAX · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q07812. Use UniProt Q07812 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q07812 as the stable identity anchor, then attach disease evidence before program review.
Apoptosis regulator BAX
Review this target as Apoptosis regulator BAX, mapped to UniProt Q07812. Sequence length is 192 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Apoptosis regulator BAX as ChEMBL target CHEMBL5318, mapped to UniProt Q07812. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Apoptosis regulator BAX |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q07812 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Apoptosis regulator BAX |
| UniProt Accession | Q07812 |
| Component Type | Protein |
| Sequence Length | 192 aa |
Apoptosis regulator BAX
Review this target as Apoptosis regulator BAX, mapped to UniProt Q07812. Sequence length is 192 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4579601 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL4868313 | 7.37 | Ki | 43.0 | Preclinical |
| CHEMBL4790235 | 6.61 | IC50 | 247.0 | Preclinical |
| CHEMBL5282360 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL4578793 | 6.59 | Kd | 255.0 | Preclinical |
| CHEMBL4790235 | 6.56 | EC50 | 278.1 | Preclinical |
| CHEMBL4794290 | 6.41 | EC50 | 392.9 | Preclinical |
| CHEMBL4779693 | 6.27 | EC50 | 537.8 | Preclinical |
| CHEMBL4784916 | 6.27 | EC50 | 531.7 | Preclinical |
| CHEMBL3417402 | 6.16 | EC50 | 700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 26 | 18 | 6.0 |
| single protein format | 6 | 7 | 6.2 |
| assay format | 5 | 23 | 5.4 |
| mitochondrion format | 3 | 0 | — |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| organism-based format | 1 | 0 | — |