Thymidylate synthase · SINGLE PROTEIN · Lactobacillus casei
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As of 2026-09-14Protein identity stays anchored to UniProt P00469. Use UniProt P00469 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00469 as the stable identity anchor, then attach disease evidence before program review.
Thymidylate synthase
Review this target as Thymidylate synthase, mapped to UniProt P00469. Sequence length is 316 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thymidylate synthase as ChEMBL target CHEMBL5328, mapped to UniProt P00469. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thymidylate synthase is the right protein anchor across sources, using UniProt P00469 as the stable mapping.
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| Preferred Name | Thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Lactobacillus casei |
| UniProt | P00469 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thymidylate synthase |
| UniProt Accession | P00469 |
| Component Type | Protein |
| Sequence Length | 316 aa |
Thymidylate synthase
Review this target as Thymidylate synthase, mapped to UniProt P00469. Sequence length is 316 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL360758 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL362606 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL360335 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL179448 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL425692 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL265510 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL389051 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL389051 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL886 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL1160181 | 7.89 | IC50 | 13.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 184 | 192 | 5.7 |
| assay format | 1 | 0 | — |
| cell-based format | 1 | 5 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 4.4 |