Mitogen-activated protein kinase kinase kinase kinase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q12851. Use UniProt Q12851 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q12851 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase kinase 2
Review this target as Mitogen-activated protein kinase kinase kinase kinase 2, mapped to UniProt Q12851. Sequence length is 820 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase kinase 2 as ChEMBL target CHEMBL5330, mapped to UniProt Q12851. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q12851 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase kinase 2 |
| UniProt Accession | Q12851 |
| Component Type | Protein |
| Sequence Length | 820 aa |
Mitogen-activated protein kinase kinase kinase kinase 2
Review this target as Mitogen-activated protein kinase kinase kinase kinase 2, mapped to UniProt Q12851. Sequence length is 820 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.32 | IC50 | 0.481 | Preclinical |
| CHEMBL4214342 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1994669 | 8.7 | Ki | 1.995 | Preclinical |
| CHEMBL4202685 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4207036 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL288441 | 8.51 | Kd | 3.1 | Approved |
| CHEMBL1984548 | 8.5 | Ki | 3.162 | Preclinical |
| CHEMBL244378 | 8.5 | Ki | 3.162 | Preclinical |
| CHEMBL4116008 | 8.4 | IC50 | 4.0 | Clinical |
| CHEMBL603469 | 8.33 | Kd | 4.7 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 205 | 120 | 6.8 |
| cell-based format | 29 | 3 | 7.2 |
| assay format | 27 | 4 | 7.0 |
| subcellular format | 22 | 36 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 457 | 6.2 |