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Target Snapshot

CHEMBL5337 Target Snapshot

Carbonic anhydrase · SINGLE PROTEIN · Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

196Compounds
16Assays
16Approved Drugs
223.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q5AJ71. Use UniProt Q5AJ71 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5AJ71 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase as ChEMBL target CHEMBL5337, mapped to UniProt Q5AJ71. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase
SINGLE PROTEIN · Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
As of 2026-09-14
ChEMBL target ID
CHEMBL5337
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q5AJ71
Carbonic anhydrase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase is the right protein anchor across sources, using UniProt Q5AJ71 as the stable mapping.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase
UniProt AccessionQ5AJ71
Component TypeProtein
Sequence Length281 aa

Carbonic anhydrase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase, mapped to UniProt Q5AJ71. Sequence length is 281 aa.

Mapped IDQ5AJ71
Review nameCarbonic anhydrase
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Clinical Profile

Clinical Phase Distribution

16
Approved
4
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

KI223.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL501294 8.29 Ki 5.1 Preclinical
CHEMBL1092054 8.12 Ki 7.5 Preclinical
CHEMBL469126 7.72 Ki 19.0 Preclinical
CHEMBL468294 7.68 Ki 21.0 Preclinical
CHEMBL3785289 7.66 Ki 21.7 Preclinical
CHEMBL468094 7.62 Ki 24.0 Preclinical
CHEMBL513854 7.54 Ki 29.0 Preclinical
CHEMBL467258 7.51 Ki 31.0 Preclinical
CHEMBL513835 7.48 Ki 33.0 Preclinical
CHEMBL3765353 7.47 Ki 34.1 Preclinical
Distribution

pChEMBL Value Distribution

15
5.0
52
5.5
49
6.0
30
6.5
42
7.0
6
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VALDECOXIB
CHEMBL865
Approved 2001
ZONISAMIDE
CHEMBL750
Approved 2000
DORZOLAMIDE
CHEMBL218490
Approved 1994
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

16
Total Assays
178
Tested Compounds
1
Assay Types
Binding — 16 assays, 178 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 128 6.1
assay format 3 50 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine