11-beta-hydroxysteroid dehydrogenase type 1 · SINGLE PROTEIN · Canis lupus familiaris
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As of 2026-09-15Protein identity stays anchored to UniProt Q5XX84. Use UniProt Q5XX84 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5XX84 as the stable identity anchor, then attach disease evidence before program review.
11-beta-hydroxysteroid dehydrogenase 1
Review this target as 11-beta-hydroxysteroid dehydrogenase type 1, mapped to UniProt Q5XX84. ChEMBL maps the protein component as 11-beta-hydroxysteroid dehydrogenase 1. Sequence length is 293 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 11-beta-hydroxysteroid dehydrogenase type 1 as ChEMBL target CHEMBL5342, mapped to UniProt Q5XX84. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 11-beta-hydroxysteroid dehydrogenase type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
| UniProt | Q5XX84 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 11-beta-hydroxysteroid dehydrogenase 1 |
| UniProt Accession | Q5XX84 |
| Component Type | Protein |
| Sequence Length | 293 aa |
11-beta-hydroxysteroid dehydrogenase 1
Review this target as 11-beta-hydroxysteroid dehydrogenase type 1, mapped to UniProt Q5XX84. ChEMBL maps the protein component as 11-beta-hydroxysteroid dehydrogenase 1. Sequence length is 293 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL455907 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL455907 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL495841 | 6.92 | EC50 | 120.0 | Preclinical |
| CHEMBL2153191 | 5.42 | IC50 | 3770.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 3 | 6.6 |
| assay format | 1 | 1 | 7.9 |