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Evidence Snapshot

Protective antigen

CHEMBL5352 SINGLE PROTEIN Bacillus anthracis
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:50:57Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5352
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protective antigen as ChEMBL target CHEMBL5352, mapped to UniProt P13423. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protective antigen
SINGLE PROTEIN · Bacillus anthracis
As of 2026-09-13
ChEMBL target ID
CHEMBL5352
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P13423
Protective antigen
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Protective antigen matters

As of 2026-09-13

Protective antigen is reviewed as Protective antigen (UniProt P13423); Protective antigen shows approved-linked disease relevance led by anthrax infection. 1 more disease program remain visible in the same review block.; 5 linked drugs keep this evidence frame grounded.; the current evidence base includes 0 approved drugs, 11 compounds, and 31 assays, with lead potency reaching pChEMBL 6.0.

Disease context
anthrax infection

Protective antigen shows approved-linked disease relevance led by anthrax infection. 1 more disease program remain visible in the same review block. 5 linked drugs keep the rationale reviewable. 1 additional disease programs remain visible in the same card. Linked drugs include AVP-21D9, BACILLUS ANTHRACIS PROTECTIVE ANTIGEN, ADSORBED, MDX-1303.

Start review with anthrax infection because it currently carries approved-linked support. Linked drugs include AVP-21D9, BACILLUS ANTHRACIS PROTECTIVE ANTIGEN, ADSORBED, MDX-1303, OBILTOXAXIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 5 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 0 approved drugs, 11 compounds, and 31 assays for this target. The dominant activity type is EC50. CHEMBL2179141 is the current potency anchor at pChEMBL 6.0.

Use CHEMBL2179141 as the tractability anchor when discussing potency (pChEMBL 6.0).

Activity source · ChEMBL 36 via Core Engine
pChEMBL 6.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Protective antigen matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P13423, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why anthrax infection is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

11
Total Compounds
31
Total Assays
0
Approved Drugs
EC50: 8.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL2179141
 6.0 EC50 —
No preferred name
CHEMBL2179142
 6.0 EC50 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:50:57Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5352