Sortase A · SINGLE PROTEIN · Staphylococcus aureus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q9S446. Use UniProt Q9S446 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9S446 as the stable identity anchor, then attach disease evidence before program review.
Sortase
Review this target as Sortase A, mapped to UniProt Q9S446. ChEMBL maps the protein component as Sortase. Sequence length is 206 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sortase A as ChEMBL target CHEMBL5362, mapped to UniProt Q9S446. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sortase A is the right protein anchor across sources, using UniProt Q9S446 as the stable mapping.
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| Preferred Name | Sortase A |
| Target Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
| UniProt | Q9S446 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sortase |
| UniProt Accession | Q9S446 |
| Component Type | Protein |
| Sequence Length | 206 aa |
Sortase
Review this target as Sortase A, mapped to UniProt Q9S446. ChEMBL maps the protein component as Sortase. Sequence length is 206 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5290944 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL5269466 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL5268517 | 6.66 | IC50 | 220.0 | Preclinical |
| CHEMBL5174805 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL9470 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL4127840 | 6.44 | IC50 | 360.0 | Preclinical |
| CHEMBL5290647 | 6.39 | IC50 | 410.0 | Preclinical |
| CHEMBL5573262 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL5574890 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL5290303 | 6.27 | IC50 | 540.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 83 | 194 | 5.1 |
| assay format | 24 | 91 | 5.1 |
| cell-based format | 18 | 11 | 5.2 |