Serine/threonine-protein kinase NLK · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9UBE8. Use UniProt Q9UBE8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UBE8 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase NLK
Review this target as Serine/threonine-protein kinase NLK, mapped to UniProt Q9UBE8. Sequence length is 527 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase NLK as ChEMBL target CHEMBL5364, mapped to UniProt Q9UBE8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase NLK |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UBE8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase NLK |
| UniProt Accession | Q9UBE8 |
| Component Type | Protein |
| Sequence Length | 527 aa |
Serine/threonine-protein kinase NLK
Review this target as Serine/threonine-protein kinase NLK, mapped to UniProt Q9UBE8. Sequence length is 527 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3752910 | 8.91 | Kd | 1.232 | Preclinical |
| CHEMBL1964692 | 8.6 | Ki | 2.512 | Preclinical |
| CHEMBL400402 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL272453 | 8.4 | Ki | 3.981 | Preclinical |
| CHEMBL1968406 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL2000335 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL1230122 | 8.22 | Kd | 6.0 | Preclinical |
| CHEMBL5090394 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5653589 | 7.79 | Kd | 16.07 | Preclinical |
| CHEMBL1242373 | 7.7 | Ki | 19.95 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 164 | 30 | 6.6 |
| assay format | 22 | 11 | 6.3 |
| cell-based format | 12 | 1 | 6.0 |
| subcellular format | 1 | 9 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 17 | 7.3 |