Hepatitis C virus NS5B RNA-dependent RNA polymerase · SINGLE PROTEIN · Hepatitis C virus
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As of 2026-09-13Protein identity stays anchored to UniProt Q8JXU8. Use UniProt Q8JXU8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8JXU8 as the stable identity anchor, then attach disease evidence before program review.
RNA-directed RNA polymerase
Review this target as Hepatitis C virus NS5B RNA-dependent RNA polymerase, mapped to UniProt Q8JXU8. ChEMBL maps the protein component as RNA-directed RNA polymerase. Sequence length is 231 aa.
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This review treats Hepatitis C virus NS5B RNA-dependent RNA polymerase as ChEMBL target CHEMBL5375, mapped to UniProt Q8JXU8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Hepatitis C virus NS5B RNA-dependent RNA polymerase |
| Target Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus |
| UniProt | Q8JXU8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RNA-directed RNA polymerase |
| UniProt Accession | Q8JXU8 |
| Component Type | Protein |
| Sequence Length | 231 aa |
RNA-directed RNA polymerase
Review this target as Hepatitis C virus NS5B RNA-dependent RNA polymerase, mapped to UniProt Q8JXU8. ChEMBL maps the protein component as RNA-directed RNA polymerase. Sequence length is 231 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3545363 | 10.28 | Ki | 0.053 | Approved |
| CHEMBL230744 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3039514 | 8.52 | EC50 | 3.0 | Approved |
| CHEMBL509746 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5937877 | 8.3 | EC50 | 5.0 | Preclinical |
| CHEMBL5889149 | 8.22 | EC50 | 6.0 | Preclinical |
| CHEMBL490672 | 8.15 | IC50 | 7.0 | Clinical |
| CHEMBL489295 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL490671 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL5783938 | 7.47 | EC50 | 34.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 18 | 6.7 |
| assay format | 1 | 38 | 6.4 |