5-hydroxytryptamine receptor 2A · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P35363. Use UniProt P35363 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35363 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P35363. Sequence length is 471 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 2A as ChEMBL target CHEMBL5377, mapped to UniProt P35363. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 2A is the right protein anchor across sources, using UniProt P35363 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 2A |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P35363 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2A |
| UniProt Accession | P35363 |
| Component Type | Protein |
| Sequence Length | 471 aa |
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P35363. Sequence length is 471 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL39 | 9.28 | EC50 | 0.5248 | Clinical |
| CHEMBL65547 | 8.01 | EC50 | 9.772 | Clinical |
| CHEMBL4648350 | 7.72 | EC50 | 19.0 | Preclinical |
| CHEMBL3942898 | 6.43 | Ki | 374.0 | Preclinical |
| CHEMBL3946661 | 6.09 | Ki | 817.0 | Preclinical |
| CHEMBL3946540 | 5.89 | Ki | 1275.0 | Preclinical |
| CHEMBL3986651 | 5.85 | Ki | 1399.0 | Preclinical |
| CHEMBL4110074 | 5.83 | Ki | 1482.0 | Preclinical |
| CHEMBL4114519 | 5.74 | Ki | 1815.0 | Preclinical |
| CHEMBL3900699 | 5.71 | Ki | 1945.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 5 | 0 | — |
| cell-based format | 4 | 3 | 8.3 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 15 | 5.7 |