Signal transducer and activator of transcription 5A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P42229. Use UniProt P42229 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42229 as the stable identity anchor, then attach disease evidence before program review.
Signal transducer and activator of transcription 5A
Review this target as Signal transducer and activator of transcription 5A, mapped to UniProt P42229. Sequence length is 794 aa.
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This review treats Signal transducer and activator of transcription 5A as ChEMBL target CHEMBL5403, mapped to UniProt P42229. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Signal transducer and activator of transcription 5A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42229 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Signal transducer and activator of transcription 5A |
| UniProt Accession | P42229 |
| Component Type | Protein |
| Sequence Length | 794 aa |
Signal transducer and activator of transcription 5A
Review this target as Signal transducer and activator of transcription 5A, mapped to UniProt P42229. Sequence length is 794 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL574058 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL603469 | 8.0 | IC50 | 10.0 | Clinical |
| CHEMBL1231124 | 7.6 | IC50 | 25.0 | Clinical |
| CHEMBL5397297 | 7.4 | EC50 | 40.0 | Preclinical |
| CHEMBL5954872 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL5856025 | 7.24 | IC50 | 57.0 | Preclinical |
| CHEMBL5783803 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL1078178 | 6.4 | IC50 | 400.0 | Approved |
| CHEMBL3108909 | 6.33 | Kd | 464.0 | Preclinical |
| CHEMBL559787 | 6.16 | IC50 | 689.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 140 | 27 | 6.0 |
| single protein format | 12 | 20 | 5.4 |
| tissue-based format | 4 | 0 | — |
| assay format | 3 | 3 | 5.3 |