Serine/threonine-protein kinase tousled-like 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q86UE8. Use UniProt Q86UE8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q86UE8 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase tousled-like 2
Review this target as Serine/threonine-protein kinase tousled-like 2, mapped to UniProt Q86UE8. Sequence length is 772 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase tousled-like 2 as ChEMBL target CHEMBL5404, mapped to UniProt Q86UE8. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Serine/threonine-protein kinase tousled-like 2 is the right protein anchor across sources, using UniProt Q86UE8 as the stable mapping.
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| Preferred Name | Serine/threonine-protein kinase tousled-like 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q86UE8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase tousled-like 2 |
| UniProt Accession | Q86UE8 |
| Component Type | Protein |
| Sequence Length | 772 aa |
Serine/threonine-protein kinase tousled-like 2
Review this target as Serine/threonine-protein kinase tousled-like 2, mapped to UniProt Q86UE8. Sequence length is 772 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 8.57 | IC50 | 2.71 | Preclinical |
| CHEMBL5549938 | 8.04 | IC50 | 9.1 | Preclinical |
| CHEMBL5505789 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5505914 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL5555013 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL388978 | 7.8 | Kd | 16.0 | Preclinical |
| CHEMBL5555697 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL5204542 | 7.73 | IC50 | 18.65 | Preclinical |
| CHEMBL5556475 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL5505934 | 7.58 | IC50 | 26.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 120 | 96 | 6.6 |
| cell-based format | 26 | 3 | 7.3 |
| subcellular format | 19 | 0 | — |
| assay format | 18 | 0 | — |