Serine/threonine-protein kinase TBK1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9UHD2. Use UniProt Q9UHD2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UHD2 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase TBK1
Review this target as Serine/threonine-protein kinase TBK1, mapped to UniProt Q9UHD2. Sequence length is 729 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase TBK1 as ChEMBL target CHEMBL5408, mapped to UniProt Q9UHD2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase TBK1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UHD2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase TBK1 |
| UniProt Accession | Q9UHD2 |
| Component Type | Protein |
| Sequence Length | 729 aa |
Serine/threonine-protein kinase TBK1
Review this target as Serine/threonine-protein kinase TBK1, mapped to UniProt Q9UHD2. Sequence length is 729 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3604928 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5743492 | 9.48 | IC50 | 0.33 | Preclinical |
| CHEMBL5985679 | 9.32 | IC50 | 0.48 | Preclinical |
| CHEMBL6002719 | 9.32 | IC50 | 0.473 | Preclinical |
| CHEMBL5742193 | 9.31 | IC50 | 0.49 | Preclinical |
| CHEMBL5976946 | 9.3 | IC50 | 0.503 | Preclinical |
| CHEMBL5969068 | 9.25 | IC50 | 0.566 | Preclinical |
| CHEMBL5758899 | 9.25 | IC50 | 0.564 | Preclinical |
| CHEMBL5955330 | 9.25 | IC50 | 0.558 | Preclinical |
| CHEMBL5815915 | 9.21 | IC50 | 0.62 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 314 | 1,518 | 6.7 |
| cell-based format | 55 | 717 | 7.3 |
| assay format | 32 | 114 | 6.2 |
| subcellular format | 28 | 33 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 81 | 5.9 |
| cell-based format | 1 | 1 | 7.1 |