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Target Snapshot

CHEMBL5413 Target Snapshot

KiSS-1 receptor · SINGLE PROTEIN · Homo sapiens

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337Compounds
48Assays
0Approved Drugs
480.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q969F8. Use UniProt Q969F8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q969F8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KiSS-1 receptor as ChEMBL target CHEMBL5413, mapped to UniProt Q969F8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KiSS-1 receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5413
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q969F8
KiSS-1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KiSS-1 receptor is the right protein anchor across sources, using UniProt Q969F8 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKiSS-1 receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ969F8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKiSS-1 receptor
UniProt AccessionQ969F8
Component TypeProtein
Sequence Length398 aa

KiSS-1 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KiSS-1 receptor, mapped to UniProt Q969F8. Sequence length is 398 aa.

Mapped IDQ969F8
Review nameKiSS-1 receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50138.0
KI113.0
EC50229.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4539775 10.66 EC50 0.022 Preclinical
CHEMBL2152055 10.64 EC50 0.023 Preclinical
CHEMBL4533110 10.62 EC50 0.024 Preclinical
CHEMBL3315315 10.59 Ki 0.026 Preclinical
CHEMBL3314227 10.57 Ki 0.027 Preclinical
CHEMBL3314217 10.55 Ki 0.028 Preclinical
CHEMBL4462883 10.55 EC50 0.028 Preclinical
CHEMBL2152060 10.54 EC50 0.029 Preclinical
CHEMBL3086282 10.49 Ki 0.032 Preclinical
CHEMBL3087927 10.48 Ki 0.033 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
9
5.5
22
6.0
24
6.5
22
7.0
51
7.5
55
8.0
58
8.5
58
9.0
51
9.5
pChEMBL
Assay Landscape

Assay Landscape

48
Total Assays
218
Tested Compounds
2
Assay Types
Functional — 24 assays, 218 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 217 8.5
assay format 3 1 6.0
Binding — 24 assays, 186 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 69 7.8
cell-based format 9 116 8.5
assay format 1 1 10.1
cell membrane format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine