Protein disulfide-isomerase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P07237. Use UniProt P07237 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07237 as the stable identity anchor, then attach disease evidence before program review.
Protein disulfide-isomerase
Review this target as Protein disulfide-isomerase, mapped to UniProt P07237. Sequence length is 508 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein disulfide-isomerase as ChEMBL target CHEMBL5422, mapped to UniProt P07237. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Protein disulfide-isomerase is the right protein anchor across sources, using UniProt P07237 as the stable mapping.
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| Preferred Name | Protein disulfide-isomerase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P07237 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein disulfide-isomerase |
| UniProt Accession | P07237 |
| Component Type | Protein |
| Sequence Length | 508 aa |
Protein disulfide-isomerase
Review this target as Protein disulfide-isomerase, mapped to UniProt P07237. Sequence length is 508 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4748449 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4637290 | 7.21 | Kd | 62.0 | Preclinical |
| CHEMBL4786482 | 7.14 | IC50 | 72.0 | Preclinical |
| CHEMBL1369923 | 7.04 | IC50 | 92.0 | Preclinical |
| CHEMBL3741464 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4483086 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL1319324 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL4472710 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL4740031 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL1688556 | 6.82 | IC50 | 150.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 35 | 144 | 6.0 |
| single protein format | 14 | 33 | 5.7 |
| cell-based format | 8 | 22 | 5.9 |
| subcellular format | 2 | 0 | — |
| biochemical format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| biochemical format | 4 | 0 | — |
| cell-based format | 1 | 0 | — |