Mitogen-activated protein kinase kinase kinase kinase 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8IVH8. Use UniProt Q8IVH8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8IVH8 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase kinase 3
Review this target as Mitogen-activated protein kinase kinase kinase kinase 3, mapped to UniProt Q8IVH8. Sequence length is 894 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase kinase 3 as ChEMBL target CHEMBL5432, mapped to UniProt Q8IVH8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase kinase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8IVH8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase kinase 3 |
| UniProt Accession | Q8IVH8 |
| Component Type | Protein |
| Sequence Length | 894 aa |
Mitogen-activated protein kinase kinase kinase kinase 3
Review this target as Mitogen-activated protein kinase kinase kinase kinase 3, mapped to UniProt Q8IVH8. Sequence length is 894 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 10.08 | IC50 | 0.0825 | Preclinical |
| CHEMBL4780798 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL5505932 | 9.31 | IC50 | 0.49 | Preclinical |
| CHEMBL5428695 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL4778959 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL4749141 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5396693 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4762312 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL288441 | 8.29 | Kd | 5.1 | Approved |
| CHEMBL5397290 | 8.15 | IC50 | 7.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 113 | 116 | 6.9 |
| assay format | 17 | 0 | — |
| cell-based format | 10 | 11 | 6.4 |
| subcellular format | 6 | 32 | 6.0 |