5-hydroxytryptamine receptor 1D · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P28565. Use UniProt P28565 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28565 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 1D
Review this target as 5-hydroxytryptamine receptor 1D, mapped to UniProt P28565. Sequence length is 374 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1D as ChEMBL target CHEMBL5450, mapped to UniProt P28565. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 1D is the right protein anchor across sources, using UniProt P28565 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 1D |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P28565 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1D |
| UniProt Accession | P28565 |
| Component Type | Protein |
| Sequence Length | 374 aa |
5-hydroxytryptamine receptor 1D
Review this target as 5-hydroxytryptamine receptor 1D, mapped to UniProt P28565. Sequence length is 374 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL83597 | 8.89 | EC50 | 1.3 | Preclinical |
| CHEMBL84107 | 8.89 | EC50 | 1.3 | Preclinical |
| CHEMBL314213 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL84942 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL39 | 8.52 | IC50 | 3.0 | Clinical |
| CHEMBL83597 | 8.51 | IC50 | 3.1 | Preclinical |
| CHEMBL39 | 8.28 | EC50 | 5.2 | Clinical |
| CHEMBL84107 | 8.21 | IC50 | 6.2 | Preclinical |
| CHEMBL314213 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL95387 | 8.0 | Ki | 10.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 9 | 7.1 |
| cell-based format | 4 | 0 | — |
| assay format | 1 | 15 | 7.2 |
| cell membrane format | 1 | 0 | — |
| tissue-based format | 1 | 17 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 6 | 8.4 |
| cell-based format | 1 | 0 | — |