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Target Snapshot

CHEMBL5462 Target Snapshot

Baculoviral IAP repeat-containing protein 2 · SINGLE PROTEIN · Homo sapiens

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832Compounds
128Assays
0Approved Drugs
986.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q13490. Use UniProt Q13490 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13490 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Baculoviral IAP repeat-containing protein 2 as ChEMBL target CHEMBL5462, mapped to UniProt Q13490. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Baculoviral IAP repeat-containing protein 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5462
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q13490
Baculoviral IAP repeat-containing protein 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Baculoviral IAP repeat-containing protein 2 is the right protein anchor across sources, using UniProt Q13490 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameBaculoviral IAP repeat-containing protein 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ13490
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBaculoviral IAP repeat-containing protein 2
UniProt AccessionQ13490
Component TypeProtein
Sequence Length618 aa

Baculoviral IAP repeat-containing protein 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Baculoviral IAP repeat-containing protein 2, mapped to UniProt Q13490. Sequence length is 618 aa.

Mapped IDQ13490
Review nameBaculoviral IAP repeat-containing protein 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase III
5
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50821.0
KI90.0
EC5067.0
KD8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3108817 10.0 EC50 0.1 Preclinical
CHEMBL3108819 10.0 EC50 0.1 Preclinical
CHEMBL3108827 10.0 EC50 0.1 Preclinical
CHEMBL3108931 10.0 EC50 0.1 Preclinical
CHEMBL4166057 10.0 IC50 0.1 Preclinical
CHEMBL4167141 9.89 IC50 0.13 Preclinical
CHEMBL4171490 9.77 IC50 0.17 Preclinical
CHEMBL4169478 9.74 IC50 0.18 Preclinical
CHEMBL4166607 9.72 IC50 0.19 Preclinical
CHEMBL3108818 9.7 EC50 0.2 Preclinical
Distribution

pChEMBL Value Distribution

28
5.0
41
5.5
94
6.0
92
6.5
109
7.0
126
7.5
109
8.0
103
8.5
85
9.0
12
9.5
pChEMBL
Assay Landscape

Assay Landscape

128
Total Assays
645
Tested Compounds
2
Assay Types
Binding — 125 assays, 645 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 60 91 8.2
single protein format 52 521 7.4
assay format 13 33 7.5
Functional — 3 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 16 7.0
assay format 1 37 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine