von Hippel-Lindau disease tumor suppressor/Nicotinamide phosphoribosyltransferase · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P43490. Use UniProt P43490 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P43490 as the stable identity anchor, then attach disease evidence before program review.
Nicotinamide phosphoribosyltransferase
Review this target as von Hippel-Lindau disease tumor suppressor/Nicotinamide phosphoribosyltransferase, mapped to UniProt P43490. ChEMBL maps the protein component as Nicotinamide phosphoribosyltransferase. Sequence length is 491 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats von Hippel-Lindau disease tumor suppressor/Nicotinamide phosphoribosyltransferase as ChEMBL target CHEMBL5465234, mapped to UniProt P43490. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | von Hippel-Lindau disease tumor suppressor/Nicotinamide phosphoribosyltransferase |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P43490 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nicotinamide phosphoribosyltransferase |
| UniProt Accession | P43490 |
| Component Type | Protein |
| Sequence Length | 491 aa |
Nicotinamide phosphoribosyltransferase
Review this target as von Hippel-Lindau disease tumor suppressor/Nicotinamide phosphoribosyltransferase, mapped to UniProt P43490. ChEMBL maps the protein component as Nicotinamide phosphoribosyltransferase. Sequence length is 491 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5434442 | 9.2 | EC50 | 0.63 | Preclinical |
| CHEMBL5432491 | 7.5 | EC50 | 31.7 | Preclinical |
| CHEMBL5428751 | 7.26 | EC50 | 54.4 | Preclinical |
| CHEMBL5398077 | 7.25 | EC50 | 56.0 | Preclinical |
| CHEMBL5401142 | 6.95 | EC50 | 111.2 | Preclinical |
| CHEMBL5404254 | 6.72 | EC50 | 189.5 | Preclinical |
| CHEMBL5394343 | 6.53 | EC50 | 293.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 57 | 7 | 7.3 |