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Target Snapshot

CHEMBL5465309 Target Snapshot

Sigma intracellular receptor 2 · SINGLE PROTEIN · Bos taurus

2Compounds
1Assays
0Approved Drugs
2.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q3MHW7. Use UniProt Q3MHW7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q3MHW7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sigma intracellular receptor 2 as ChEMBL target CHEMBL5465309, mapped to UniProt Q3MHW7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sigma intracellular receptor 2
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL5465309
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q3MHW7
Sigma intracellular receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sigma intracellular receptor 2 is the right protein anchor across sources, using UniProt Q3MHW7 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSigma intracellular receptor 2
UniProt AccessionQ3MHW7
Component TypeProtein
Sequence Length176 aa

Sigma intracellular receptor 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sigma intracellular receptor 2, mapped to UniProt Q3MHW7. Sequence length is 176 aa.

Mapped IDQ3MHW7
Review nameSigma intracellular receptor 2
OrganismBos taurus
Assay Mix

Activity Type Distribution

KI2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1215855 9.4 Ki 0.4 Preclinical
CHEMBL5440131 7.89 Ki 13.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 1 2 8.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine