Use UniProt Q3MHW7 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL5465309 Target Snapshot
Sigma intracellular receptor 2 · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt Q3MHW7. Use UniProt Q3MHW7 as the stable identity anchor, then attach disease evidence before program review.
Sigma intracellular receptor 2
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q3MHW7. Sequence length is 176 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Sigma intracellular receptor 2 as ChEMBL target CHEMBL5465309, mapped to UniProt Q3MHW7. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Sigma intracellular receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | Q3MHW7 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sigma intracellular receptor 2 |
| UniProt Accession | Q3MHW7 |
| Component Type | Protein |
| Sequence Length | 176 aa |
Sigma intracellular receptor 2
How to read this target
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q3MHW7. Sequence length is 176 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1215855 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL5440131 | 7.89 | Ki | 13.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 2 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 2 | 8.6 |