threonine--tRNA ligase · SINGLE PROTEIN · Plasmodium falciparum
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As of 2026-09-14Protein identity stays anchored to UniProt Q8IIA4. Use UniProt Q8IIA4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8IIA4 as the stable identity anchor, then attach disease evidence before program review.
threonine--tRNA ligase
Review this target as threonine--tRNA ligase, mapped to UniProt Q8IIA4. Sequence length is 1013 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats threonine--tRNA ligase as ChEMBL target CHEMBL5465377, mapped to UniProt Q8IIA4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | threonine--tRNA ligase |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
| UniProt | Q8IIA4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | threonine--tRNA ligase |
| UniProt Accession | Q8IIA4 |
| Component Type | Protein |
| Sequence Length | 1013 aa |
threonine--tRNA ligase
Review this target as threonine--tRNA ligase, mapped to UniProt Q8IIA4. Sequence length is 1013 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL70590 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL2311925 | 7.24 | IC50 | 57.0 | Preclinical |
| CHEMBL5405159 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL1163068 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL70590 | 6.8 | Ki | 160.0 | Preclinical |
| CHEMBL5438745 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL5424310 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL5430875 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL5431275 | 4.52 | IC50 | 30000.0 | Preclinical |
| CHEMBL5400120 | 4.48 | IC50 | 33000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 9 | 5.3 |
| single protein format | 1 | 5 | 6.5 |