MUS81-ECE1 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P42892. Use UniProt P42892 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42892 as the stable identity anchor, then attach disease evidence before program review.
Endothelin-converting enzyme 1
Review this target as MUS81-ECE1, mapped to UniProt P42892. ChEMBL maps the protein component as Endothelin-converting enzyme 1. Sequence length is 770 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats MUS81-ECE1 as ChEMBL target CHEMBL5465380, mapped to UniProt P42892. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether MUS81-ECE1 is the right protein anchor across sources, using UniProt P42892 as the stable mapping.
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| Preferred Name | MUS81-ECE1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P42892 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin-converting enzyme 1 |
| UniProt Accession | P42892 |
| Component Type | Protein |
| Sequence Length | 770 aa |
Endothelin-converting enzyme 1
Review this target as MUS81-ECE1, mapped to UniProt P42892. ChEMBL maps the protein component as Endothelin-converting enzyme 1. Sequence length is 770 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4071130 | 6.25 | IC50 | 560.0 | Preclinical |
| CHEMBL1200976 | 6.21 | IC50 | 610.0 | Approved |
| CHEMBL4071130 | 6.21 | Kd | 611.0 | Preclinical |
| CHEMBL2354444 | 6.1 | IC50 | 790.0 | Clinical |
| CHEMBL5394285 | 6.0 | IC50 | 990.0 | Preclinical |
| CHEMBL4084119 | 5.93 | IC50 | 1170.0 | Approved |
| CHEMBL5437637 | 5.9 | IC50 | 1270.0 | Preclinical |
| CHEMBL449392 | 5.89 | IC50 | 1290.0 | Preclinical |
| CHEMBL445177 | 5.84 | IC50 | 1450.0 | Preclinical |
| CHEMBL1241028 | 5.74 | IC50 | 1840.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 12 | 5.9 |