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Target Snapshot

CHEMBL5465386 Target Snapshot

Metallo-beta-lactamase type 2 · SINGLE PROTEIN · Bacteria

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2,259Compounds
80Assays
3Approved Drugs
2,226.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt C7C422. Use UniProt C7C422 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt C7C422 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Metallo-beta-lactamase type 2 as ChEMBL target CHEMBL5465386, mapped to UniProt C7C422. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Metallo-beta-lactamase type 2
SINGLE PROTEIN · Bacteria
As of 2026-09-14
ChEMBL target ID
CHEMBL5465386
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
C7C422
Metallo-beta-lactamase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Metallo-beta-lactamase type 2 is the right protein anchor across sources, using UniProt C7C422 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMetallo-beta-lactamase type 2
Target TypeSINGLE PROTEIN
OrganismBacteria
UniProtC7C422
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMetallo-beta-lactamase type 2
UniProt AccessionC7C422
Component TypeProtein
Sequence Length270 aa

Metallo-beta-lactamase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Metallo-beta-lactamase type 2, mapped to UniProt C7C422. Sequence length is 270 aa.

Mapped IDC7C422
Review nameMetallo-beta-lactamase type 2
OrganismBacteria
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC502,147.0
KI63.0
KD16.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5828798 10.89 IC50 0.013 Preclinical
CHEMBL5948879 10.89 IC50 0.013 Preclinical
CHEMBL5788920 10.82 IC50 0.015 Preclinical
CHEMBL5795556 10.82 IC50 0.015 Preclinical
CHEMBL5796881 10.82 IC50 0.015 Preclinical
CHEMBL5823930 10.8 IC50 0.016 Preclinical
CHEMBL6016686 10.8 IC50 0.016 Preclinical
CHEMBL5954858 10.77 IC50 0.017 Preclinical
CHEMBL5766440 10.72 IC50 0.019 Preclinical
CHEMBL5838107 10.72 IC50 0.019 Preclinical
Distribution

pChEMBL Value Distribution

48
5.0
46
5.5
74
6.0
68
6.5
114
7.0
253
7.5
321
8.0
293
8.5
269
9.0
291
9.5
pChEMBL
Assay Landscape

Assay Landscape

80
Total Assays
2,102
Tested Compounds
1
Assay Types
Binding — 80 assays, 2,102 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 40 1,960 8.7
assay format 23 103 5.4
cell-based format 17 39 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine