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Target Snapshot

CHEMBL5465393 Target Snapshot

SOS1-KRAS · PROTEIN COMPLEX · Homo sapiens

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329Compounds
35Assays
2Approved Drugs
384.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q07889. Use UniProt Q07889 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q07889 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SOS1-KRAS as ChEMBL target CHEMBL5465393, mapped to UniProt Q07889. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SOS1-KRAS
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5465393
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q07889
Son of sevenless homolog 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SOS1-KRAS is the right protein anchor across sources, using UniProt Q07889 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSOS1-KRAS
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtQ07889
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSon of sevenless homolog 1
UniProt AccessionQ07889
Component TypeProtein
Sequence Length1333 aa

Son of sevenless homolog 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SOS1-KRAS, mapped to UniProt Q07889. ChEMBL maps the protein component as Son of sevenless homolog 1. Sequence length is 1333 aa.

Mapped IDQ07889
Review nameSOS1-KRAS
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC50381.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL6000292 9.0 IC50 1.0 Preclinical
CHEMBL6009434 9.0 IC50 1.0 Preclinical
CHEMBL5745704 8.7 IC50 2.0 Preclinical
CHEMBL5781021 8.7 IC50 2.0 Preclinical
CHEMBL5846727 8.7 IC50 2.0 Preclinical
CHEMBL5884848 8.7 IC50 2.0 Preclinical
CHEMBL5889849 8.7 IC50 2.0 Preclinical
CHEMBL5905465 8.7 IC50 2.0 Preclinical
CHEMBL5907163 8.7 IC50 2.0 Preclinical
CHEMBL5914084 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
23
5.5
20
6.0
20
6.5
40
7.0
100
7.5
112
8.0
21
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ADAGRASIB
CHEMBL4594350
Approved 2022
Properties Compare Identifier
SOTORASIB
CHEMBL4535757
Approved 2021
Properties Compare Identifier
Assay Landscape

Assay Landscape

35
Total Assays
290
Tested Compounds
1
Assay Types
Binding — 35 assays, 290 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 17 203 8.0
assay format 16 82 6.9
cell-based format 2 5 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine