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Target Snapshot

CHEMBL5465447 Target Snapshot

KBv200 · CELL-LINE · Homo sapiens

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98Compounds
51Assays
4Approved Drugs
73.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KBv200 as ChEMBL target CHEMBL5465447. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KBv200
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5465447
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KBv200 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKBv200
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKBv200
UniProt AccessionN/A

KBv200

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KBv200.

Review nameKBv200
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC5073.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5399206 10.7 IC50 0.02 Preclinical
CHEMBL5399548 10.3 IC50 0.05 Preclinical
CHEMBL5440498 9.68 IC50 0.21 Preclinical
CHEMBL5405970 9.52 IC50 0.3 Preclinical
CHEMBL5411100 9.42 IC50 0.38 Preclinical
CHEMBL5438378 9.4 IC50 0.4 Preclinical
CHEMBL5401184 9.38 IC50 0.42 Preclinical
CHEMBL5414613 9.36 IC50 0.44 Preclinical
CHEMBL5412964 9.26 IC50 0.55 Preclinical
CHEMBL5437817 9.13 IC50 0.74 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
18
6.5
6
7.0
10
7.5
18
8.0
9
8.5
7
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
VERAPAMIL
CHEMBL6966
Approved 1981
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

51
Total Assays
59
Tested Compounds
1
Assay Types
Functional — 51 assays, 59 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 28 0 —
cell-based format 23 59 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine